“NITRIC OXIDE IS a gas and free radical that’s recognized to play a role in several physiological systems,” says Alex Rothstein, M.S., an instructor in the exercise science program at the New York Institute of Technology. It’s synthesized from L-arginine, an essential amino acid.
Nitric oxide acts as a vasodilator, which means it helps open blood vessels. As a result, many people take the precursor L-arginine for issues like erectile dysfunction and to improve heart health.
Nitric oxide’s role in vasodilation is also important for regulating blood pressure, says William Workman, M.D., an orthopedic surgeon and sports medicine expert at DISC Sports & Spine Center in Walnut Creek, California.
Many small blood vessels and capillaries sit dormant until you get your heart rate up during exercise, and nitric oxide enables blood to flow to these areas to allow your muscles to work, hence its reputation as a substance that can help your fitness performance.
Other important functions of nitric oxide are its roles in neurotransmission, hormone signaling, and the relaxation of blood vessels, explains Marco Anzures, M.S., C.S.C.S., owner of the coaching platform Coach You Better and an exercise science instructor at San Diego City College.
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“The research linking the consumption of the precursor molecules to increase nitric oxide and subsequently improve markers of heart health, exercise performance, and treating erectile dysfunction (to name a few) is mixed and not strongly supported by the literature,” says Anzures.
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Some research shows that L-arginine, found in nitric oxide supplements, could improve fitness performance for runners, cyclists, and swimmers. But, other research has shown little to no effect.
“The research is mixed on the purported benefits of nitric oxide supplementation and fitness performance,” Anzures says. “There is some evidence to suggest supplementation helps with endurance but not with overall performance in a time trial.”
A small study also showed that L-citrulline could help boost aerobic performance and decrease muscle soreness after working out.
A review of several studies related to the effects of dietary ingredients linked with nitric oxide and exercise performance found mixed results: the review concluded that while nitric oxide supplements may "improve tolerance" to aerobic and anaerobic exercise in people who either aren't in shape or are moderately trained, there seems to be no benefit in highly trained people.
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More research is needed to know for sure whether the supplements actually play a role in your workout performance. (But these supplements may help you get extra benefits from lifting.)
A 2020 study showed that L-arginine supplements might enhance the effects of a common erectile dysfunction drug, but studies on people without a dysfunction are limited. So, the general benefits aren’t totally known. L-citrulline might also help treat erectile dysfunction, some research suggests.
“For these individuals, an increase in L-arginine may promote vasodilation that would not otherwise occur without the onset of exercise,” he adds. “If an individual for some reason was also not ingesting enough arginine in their diet, supplementation would help offset the lack of this nutrient.”
Supplements might also reduce the cardiovascular effects of type 2 diabetes. Nitric oxide production is also hindered in people with type 2 diabetes, and this diminishes the health of blood vessels, which increases the risk of heart disease and high blood pressure.
https://dmncms.net/topic/268483-nitric-boost-ultra-reviews-and-october-2025/
Nitric oxide acts as a vasodilator, which means it helps open blood vessels. As a result, many people take the precursor L-arginine for issues like erectile dysfunction and to improve heart health.
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Nitric oxide’s role in vasodilation is also important for regulating blood pressure, says William Workman, M.D., an orthopedic surgeon and sports medicine expert at DISC Sports & Spine Center in Walnut Creek, California.
Many small blood vessels and capillaries sit dormant until you get your heart rate up during exercise, and nitric oxide enables blood to flow to these areas to allow your muscles to work, hence its reputation as a substance that can help your fitness performance.
Other important functions of nitric oxide are its roles in neurotransmission, hormone signaling, and the relaxation of blood vessels, explains Marco Anzures, M.S., C.S.C.S., owner of the coaching platform Coach You Better and an exercise science instructor at San Diego City College.
What Are Nitric Oxide Supplements?
OFTEN, NITRIC OXIDE supplements don’t actually contain nitric oxide; they just contain its precursors: L-arginine and sometimes L-citrulline. "Supplementation of these compounds provides the body with the building blocks for nitric oxide production,” Anzures says. L-arginine also helps the body build protein, according to the Mayo Clinic.Advertisement - Continue Reading Below
“The research linking the consumption of the precursor molecules to increase nitric oxide and subsequently improve markers of heart health, exercise performance, and treating erectile dysfunction (to name a few) is mixed and not strongly supported by the literature,” says Anzures.
BJI / Blue Jean Images//Getty Images
The Potential Benefits of Nitric Oxide
SO FAR, HERE'S what we know about nitric oxide and its potential benefits:Nitric Oxide Could Boost Your Fitness Performance
ONE OF THE primary functions of nitric oxide is widening blood vessels to increase blood flow, or vasodilation, Rothstein says. This helps deliver oxygen and nutrients to your muscles when you exercise, which could help you perform better and work out longer.Some research shows that L-arginine, found in nitric oxide supplements, could improve fitness performance for runners, cyclists, and swimmers. But, other research has shown little to no effect.
“The research is mixed on the purported benefits of nitric oxide supplementation and fitness performance,” Anzures says. “There is some evidence to suggest supplementation helps with endurance but not with overall performance in a time trial.”
A small study also showed that L-citrulline could help boost aerobic performance and decrease muscle soreness after working out.
A review of several studies related to the effects of dietary ingredients linked with nitric oxide and exercise performance found mixed results: the review concluded that while nitric oxide supplements may "improve tolerance" to aerobic and anaerobic exercise in people who either aren't in shape or are moderately trained, there seems to be no benefit in highly trained people.
Advertisement - Continue Reading Below
More research is needed to know for sure whether the supplements actually play a role in your workout performance. (But these supplements may help you get extra benefits from lifting.)
It Could Improve Your Blood Pressure
HIGH BLOOD PRESSURE happens when the force of the blood that pushes against the walls of your blood vessels is too high. This can cause health consequences like heart disease and stroke. The theoretical mechanism for supplementing with L-arginine to increase nitric oxide production is its role in blood flow and blood pressure regulation.It Could Help You Last Longer In Bed
THE BLOOD FLOW regulation that nitric oxide helps with plays a role in multiple body functions, including maintaining erections.A 2020 study showed that L-arginine supplements might enhance the effects of a common erectile dysfunction drug, but studies on people without a dysfunction are limited. So, the general benefits aren’t totally known. L-citrulline might also help treat erectile dysfunction, some research suggests.
It Could Help Lower Your Risk for Heart Disease
ALONG WITH HELPING improve blood pressure, nitric oxide might reduce your risk for heart disease, especially for people who don’t exercise regularly, Rothstein says.“For these individuals, an increase in L-arginine may promote vasodilation that would not otherwise occur without the onset of exercise,” he adds. “If an individual for some reason was also not ingesting enough arginine in their diet, supplementation would help offset the lack of this nutrient.”
Supplements might also reduce the cardiovascular effects of type 2 diabetes. Nitric oxide production is also hindered in people with type 2 diabetes, and this diminishes the health of blood vessels, which increases the risk of heart disease and high blood pressure.
It Might Help With Respiratory Illnesses
A STUDY FROM a team of Chinese and American researchers found that inhaled nitric oxide could potentially be a treatment for critically ill Covid-19 patients. It’s thought that nitric oxide’s vasodilation properties may serve as effective therapy not just for Covid but for other respiratory and cardiovascular conditions related to the virus.https://dmncms.net/topic/268483-nitric-boost-ultra-reviews-and-october-2025/